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Autor/inn/en | Abbeduto, Leonard; Thurman, Angela John; McDuffie, Andrea; Klusek, Jessica; Feigles, Robyn Tempero; Ted Brown, W.; Harvey, Danielle J.; Adayev, Tatyana; LaFauci, Giuseppe; Dobkins, Carl; Roberts, Jane E. |
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Titel | ASD Comorbidity in Fragile X Syndrome: Symptom Profile and Predictors of Symptom Severity in Adolescent and Young Adult Males |
Quelle | In: Journal of Autism and Developmental Disorders, 49 (2019) 3, S.960-977 (18 Seiten)
PDF als Volltext |
Sprache | englisch |
Dokumenttyp | gedruckt; online; Zeitschriftenaufsatz |
ISSN | 0162-3257 |
DOI | 10.1007/s10803-018-3796-2 |
Schlagwörter | Males; Genetic Disorders; Autism; Pervasive Developmental Disorders; Symptoms (Individual Disorders); Adolescents; Young Adults; Severity (of Disability); Language Impairments; Cognitive Ability; Behavior Problems; Interpersonal Competence; Affective Behavior; Predictor Variables; Expressive Language; Syntax; Comorbidity Male; Männliches Geschlecht; Autismus; Psychiatrische Symptomatik; Adolescent; Adolescence; Adoleszenz; Jugend; Jugendalter; Jugendlicher; Young adult; Junger Erwachsener; Schweregrad; Speech disorder; Speech disorders; Speech disabilities; Speech disability; Speech handicap; Speech handicaps; Speech impairment; Speech impairments; Language handicaps; Sprachbehinderung; Denkfähigkeit; Interpersonale Kompetenz; Affective disturbance; Active behaviour; Affektive Störung; Prädiktor |
Abstract | Many males with FXS meet criteria for ASD. This study was designed to (1) describe ASD symptoms in adolescent and young adult males with FXS (n = 44) and (2) evaluate the contributions to ASD severity of cognitive, language, and psychiatric factors, as well as FMRP (the protein deficient in FXS). A few ASD symptoms on the ADOS-2 were universal in the sample. There was less impairment in restricted and repetitive behaviors (RRB) than in the social affective (SA) domain. The best predictor of overall ASD severity and SA severity was expressive syntactic ability. RRB severity was best predicted by the psychiatric factors. Implications for clinical practice and for understanding the ASD comorbidity in FXS are discussed. (As Provided). |
Anmerkungen | Springer. Available from: Springer Nature. 233 Spring Street, New York, NY 10013. Tel: 800-777-4643; Tel: 212-460-1500; Fax: 212-348-4505; e-mail: customerservice@springernature.com; Web site: https://link.springer.com/ |
Erfasst von | ERIC (Education Resources Information Center), Washington, DC |
Update | 2020/1/01 |